Abstract
We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP(1) receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound. Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.
MeSH terms
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Heterocyclic Compounds / chemistry*
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Heterocyclic Compounds / pharmacology*
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Models, Molecular
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Molecular Structure
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Protein Binding
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Receptors, Prostaglandin E / antagonists & inhibitors*
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Receptors, Prostaglandin E, EP1 Subtype
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Structure-Activity Relationship
Substances
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Heterocyclic Compounds
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP1 Subtype